The geopolitical dynamics of Southeast Asia are currently developing rapidly, influenced by various global and regional factors. This region is the center of attention because of its strategic position as the main trade route between the Pacific and the Indian Ocean. The challenges and opportunities that arise in this context are complex and require in-depth understanding. One of the main challenges in this region is competition between big powers, especially the United States and China. China’s “Belt and Road Initiative” strategy has had a significant impact on regional infrastructure, but has also raised concerns about economic interdependence. Countries such as Indonesia, Thailand and Vietnam must balance their relations with these two powers, maintaining sovereignty while leveraging investment. Apart from that, security issues such as militancy and inter-state conflicts are also challenges. Tensions in the South China Sea are attracting global attention, with countries such as the Philippines and Vietnam strengthening their positions. Peaceful resolution through dialogue and multilateral cooperation is the desired path, although it is often hindered by the national interests of each country. The opportunities in this dynamic are no less interesting. ASEAN, as a regional bloc, plays a vital role in promoting stability and cooperation. Economic initiatives such as the ASEAN Economic Community (AEC) provide opportunities for countries to strengthen market integration and increase competitiveness. With closer collaboration, Southeast Asian countries can optimize natural and human resources. Changes in demographics, such as a large young population, also hold great potential. The millennial generation and Gen Z in Southeast Asia contribute to technological innovation and growth. The development of startups and information technology ecosystems in countries such as Singapore and Indonesia creates new investment opportunities. Amidst the challenges and opportunities, the issue of climate change cannot be ignored. Southeast Asian countries are vulnerable to natural disasters, so cooperation in disaster mitigation and energy transition is becoming increasingly important. With pilot projects for renewable energy, these countries can not only adapt, but also become leaders in green innovation. Overall, Southeast Asia’s geopolitical dynamics are strongly influenced by complex interactions between challenges and opportunities. Countries in this region must be diplomatic and strategic in facing the future, ensuring that security and economic growth can be achieved in a sustainable manner. Regional initiatives, international collaboration and local innovation will be key to optimizing Southeast Asia’s potential in this era of uncertainty.